HIV-1 Nuclear Import: Matrix Protein Is Back on Center Stage, This Time Together with Vpr
نویسندگان
چکیده
منابع مشابه
HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.
The ability of HIV-1 to transport its pre-integration complex (PIC) into the nucleus of an infected cell during interphase is a unique feature that sets this virus, and the whole group of Len-tiviruses to which it belongs, apart from other retroviruses that have to rely on the dissolution of the nuclear envelope during mitosis for delivery of their genome into the nucleus (1,2). Following initi...
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Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona fide nuclear localization signal and it is targeted Vpr(N17C74) to the nuclear envelope and then imported into the nucleus by importin α (Impα) a...
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While the Vpr protein of HIV-1 has been implicated in import of the viral preintegration complex across the nuclear pore complex (NPC) of nondividing cellular hosts, the mechanism by which Vpr enters the nucleus remains unknown. We now demonstrate that Vpr contains two discrete nuclear targeting signals that use two different import pathways, both of which are distinct from the classical nuclea...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 1998
ISSN: 1076-1551,1528-3658
DOI: 10.1007/bf03401911